Management of red blood cell alloimmunization in pregnancy.
J Gynecol Obstet Hum Reprod
; 47(5): 197-204, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29476829
ABSTRACT
The main cause of fetal anemia is maternal red blood cell alloimmunization (AI). The search of maternal antibodies by indirect antiglobulin test allows screening for AI during pregnancy. In case of AI, fetal genotyping (for Rh-D, Rh-c, Rh-E and Kell), quantification (for anti-rhesus antibodies) and antibody titration, as well as ultrasound monitoring, are performed. This surveillance aims at screening for severe anemia before hydrops fetalis occurs. Management of severe anemia is based on intrauterine transfusion (IUT) or labor induction depending on gestational age. After intrauterine transfusion, follow-up will focus on detecting recurrence of anemia and detecting fetal brain injury. With IUT, survival of fetuses with alloimmunization is greater than 90% but 4.8% of children with at least one IUT have neurodevelopmental impairment.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Isoimunização Rh
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Transfusão de Sangue Intrauterina
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Eritroblastose Fetal
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Eritrócitos
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Doenças Fetais
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Anemia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article