The Cancer Mutation D83V Induces an &#945;-Helix to ß-Strand Conformation Switch in MEF2B.

Lei, Xiao; Kou, Yi; Fu, Yang; Rajashekar, Niroop; Shi, Haoran; Wu, Fang; Xu, Jiang; Luo, Yibing; Chen, Lin

The Cancer Mutation D83V Induces an α-Helix to ß-Strand Conformation Switch in MEF2B.

Lei, Xiao; Kou, Yi; Fu, Yang; Rajashekar, Niroop; Shi, Haoran; Wu, Fang; Xu, Jiang; Luo, Yibing; Chen, Lin.

Afiliação

Lei X; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Kou Y; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University o
Fu Y; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Rajashekar N; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Shi H; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Wu F; Department of Statistics and Applied Probability, University of California, Santa Barbara, CA 93106, USA.
Xu J; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University o
Luo Y; Department of Statistics, University of California, Davis, CA 95616, USA.
Chen L; Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University o

J Mol Biol ; 430(8): 1157-1172, 2018 04 13.

Article em En | MEDLINE | ID: mdl-29477338

Assuntos

Substituição de Aminoácidos; Linfoma não Hodgkin/genética; Cristalografia por Raios X; Humanos; Fatores de Transcrição MEF2/química; Fatores de Transcrição MEF2/genética; Modelos Moleculares; Conformação Proteica em alfa-Hélice; Conformação Proteica em Folha beta; Domínios Proteicos

Palavras-chave

MEF2B; cancer mutation; lymphoma; metamorphic protein structure; protein conformation change

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Substituição de Aminoácidos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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