Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.

Motyl, Joanna; Przykaza, Lukasz; Boguszewski, Pawel M; Kosson, Piotr; Strosznajder, Joanna B

Motyl, Joanna; Przykaza, Lukasz; Boguszewski, Pawel M; Kosson, Piotr; Strosznajder, Joanna B.

Afiliação

Motyl J; Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, 5 Pawinski Street, 02-106, Warsaw, Poland. Electronic address: jmotyl@ibib.waw.pl.
Przykaza L; Laboratory of Experimental Neurosurgery, Department of Neurosurgery, Mossakowski Medical Research Centre Polish Academy of Sciences, 5 Pawinski Street, 02-106, Warsaw, Poland. Electronic address: lprzykaza@imdik.pan.pl.
Boguszewski PM; Laboratory of Animal Models, Neurobiology Centre, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland. Electronic address: pmbogusz@gmail.com.
Kosson P; Toxicology Research Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinski Street, 02-106, Warsaw, Poland. Electronic address: pkosson@imdik.pan.pl.
Strosznajder JB; Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, 5 Pawinski Street, 02-106, Warsaw, Poland. Electronic address: jstrosznajder@imdik.pan.pl.

Neuropharmacology ; 135: 139-150, 2018 06.

Article em En | MEDLINE | ID: mdl-29481916

Assuntos

Cloridrato de Fingolimode/farmacologia; Intoxicação por MPTP/prevenção & controle; Neuroproteção/efeitos dos fármacos; Doença de Parkinson/enzimologia; Doença de Parkinson/prevenção & controle; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Pramipexol/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina; Animais; Encéfalo/metabolismo; Intoxicação por MPTP/metabolismo; Masculino; Camundongos; Fosforilação; Teste de Desempenho do Rota-Rod; Tirosina 3-Mono-Oxigenase/metabolismo; Proteína de Morte Celular Associada a bcl/metabolismo

Palavras-chave

Fingolimod; MPTP; Parkinson's disease; Pramipexole; Sphingosine kinase 1; Sphingosine-1-phosphate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fosfotransferases (Aceptor do Grupo Álcool) / Intoxicação por MPTP / Proteínas Proto-Oncogênicas c-akt / Cloridrato de Fingolimode / Neuroproteção / Pramipexol Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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