The effect of combined photobiomodulation and curcumin on skin wound healing in type I diabetes in rats.
J Photochem Photobiol B
; 181: 23-30, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29486459
ABSTRACT
The purpose of the present scientific study was to analyze the effects of combined pulsed wave Photobiomodulation (PW PBM) and Curcumin on the microbial flora; in addition, the tensiometrical wounds properties for type one diabetes mellitus (TIDM) in an experimental animal model. TIDM induction was performed in thirty rats. In the entire animals, one full-thickness excision was implemented on their backs. Randomly, the divisions of rats into 5 groups took place. The primary group was considered as the control group and did not receive any treatment. The secondary group (placebo) received sesame oil by gastric gavage. The third group received PWPBM (890â¯nm, 80â¯Hz, 0.2â¯J/cm2). The fourth group received curcumin (40â¯mg/kg, which was dissolved in sesame oil) by gastric gavage. Eventually, the fifth group received PW PBMâ¯+â¯curcumin. Precisely, on day 7, microbiological examinations, and on the 15th day microbiological and tensiometrical examinations were conducted. The data were analyzed by statistical tests. PW PBM, significantly exacerbated tensiometrical properties of the TIDM repairing wound. PW PBM, curcumin, and PWPBMâ¯+â¯curcumin significantly decreased colony forming units compared to the control and the placebo groups indeed. It was remarkably attained that PW PBM significantly accelerated the process of wound healing in the STZ-induced TIDM. The PW PBM was statistically more compelling compared to the curcumin and PWPBMâ¯+â¯curcumin. PW PBM, curcumin, and PWPBMâ¯+â¯curcumin significantly decreased colony forming units compared to the control and placebo groups.
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Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Fármacos Fotossensibilizantes
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Curcumina
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article