Amikacin-containing self-emulsifying delivery systems via pulmonary administration for treatment of bacterial infections of cystic fibrosis patients.
Nanomedicine (Lond)
; 13(7): 717-732, 2018 04 01.
Article
em En
| MEDLINE
| ID: mdl-29488425
ABSTRACT
AIM:
The aim of the study was to develop self-emulsifying delivery systems (SEDDS) exhibiting improved permeation rate for pulmonary delivery of amikacin for treatment of cystic fibrosis (CF) patients. MATERIALS &METHODS:
Solubility of amikacin in lipids was improved by hydrophobic ion pairing with sodium myristyl sulfate. The complex was loaded into SEDDS. Drug-release studies were performed and the permeation properties of SEDDS through human CF mucus were examined.RESULTS:
A total of 10% complex could be loaded into SEDDS. SEDDS exhibited sustained release. Up to twofold more amounts of amikacin permeated through the CF mucus compared with reference.CONCLUSION:
The developed SEDDS with amikacin may be a promising tool for the treatment of certain bacterial infections of CF patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Amicacina
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Sistemas de Liberação de Medicamentos
/
Fibrose Cística
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article