Elucidating an Amorphous Form Stabilization Mechanism for Tenapanor Hydrochloride: Crystal Structure Analysis Using X-ray Diffraction, NMR Crystallography, and Molecular Modeling.

Nilsson Lill, Sten O; Widdifield, Cory M; Pettersen, Anna; Svensk Ankarberg, Anna; Lindkvist, Maria; Aldred, Peter; Gracin, Sandra; Shankland, Norman; Shankland, Kenneth; Schantz, Staffan; Emsley, Lyndon

Nilsson Lill, Sten O; Widdifield, Cory M; Pettersen, Anna; Svensk Ankarberg, Anna; Lindkvist, Maria; Aldred, Peter; Gracin, Sandra; Shankland, Norman; Shankland, Kenneth; Schantz, Staffan; Emsley, Lyndon.

Afiliação

Nilsson Lill SO; Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.
Widdifield CM; Institut des Sciences Analytiques (CNRS/ENS de Lyon/UCB Lyon 1), Centre de RMN à Très Hauts Champs , Université de Lyon , 69100 Villeurbanne , France.
Pettersen A; Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.
Svensk Ankarberg A; Pharmaceutical Technology & Development , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.
Lindkvist M; Pharmaceutical Technology & Development , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.
Aldred P; Pharmaceutical Technology & Development , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.
Gracin S; Pharmaceutical Technology & Development , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.
Shankland N; CrystallografX Ltd , 2 Stewart Street , Milngavie, Glasgow G62 6BW , United Kingdom.
Shankland K; CrystallografX Ltd , 2 Stewart Street , Milngavie, Glasgow G62 6BW , United Kingdom.
Schantz S; School of Pharmacy , University of Reading , Whiteknights, P.O. Box 224, Reading , RG6 6AD , United Kingdom.
Emsley L; Pharmaceutical Technology & Development , AstraZeneca Gothenburg , SE-431 83 , Mölndal , Sweden.

Mol Pharm ; 15(4): 1476-1487, 2018 04 02.

Article em En | MEDLINE | ID: mdl-29490140

Assuntos

Isoquinolinas/química; Sulfonamidas/química; Cristalização/métodos; Cristalografia por Raios X/métodos; Espectroscopia de Ressonância Magnética/métodos; Modelos Moleculares; Conformação Molecular; Pós/química; Sais/química; Difração de Raios X/métodos

Palavras-chave

X-ray diffraction; amorphous; crystal structure; density functional theory; solid-state NMR; stabilization

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Isoquinolinas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Isoquinolinas Idioma: En Ano de publicação: 2018 Tipo de documento: Article