Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - A systematic review.
Early Hum Dev
; 120: 80-87, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29496329
ABSTRACT
AIMS:
Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE.METHODS:
Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18â¯months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean.RESULT:
Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome.CONCLUSION:
A significant proportion of infants with mild HIE have abnormal outcome at follow up.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Hipotermia Induzida
/
Doenças do Recém-Nascido
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article