The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.

Peng, Dian; Cao, Bin; Zhou, Ying-Jun; Long, Ya-Qiu

Peng, Dian; Cao, Bin; Zhou, Ying-Jun; Long, Ya-Qiu.

Afiliação

Peng D; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Cao B; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhou YJ; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Long YQ; College of Pharmaceutical Sciences, Soochow University Medical College, Suzhou 215123, China. Electronic address: longyaqiu@suda.edu.cn.

Eur J Med Chem ; 149: 148-169, 2018 Apr 10.

Article em En | MEDLINE | ID: mdl-29500940

Assuntos

Descoberta de Drogas/tendências; Tratamento Farmacológico/métodos; Receptores CXCR4/antagonistas & inibidores; Quimiocina CXCL12/metabolismo; Descoberta de Drogas/métodos; Tratamento Farmacológico/tendências; Humanos; Ligantes; Receptores CXCR4/metabolismo

Palavras-chave

Autoimmune; CXC chemokine receptor 4; HIV-1 entry; Inflammation; Ischemia-reperfusion; Small molecule antagonists; Structure-based optimization; Tumor metastasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Tratamento Farmacológico / Descoberta de Drogas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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