Disease-Drug Interactions in Inflammatory States via Effects on CYP-Mediated Drug Clearance.
J Clin Pharmacol
; 58(7): 849-863, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29505093
ABSTRACT
The human inflammatory response can result in the alteration of drug clearance through effects on drug-metabolizing enzymes or drug transporters. In this article, clinical examples are reviewed of how diseases with moderate to severe inflammation can decrease cytochrome P450 (CYP)-mediated drug clearance and alter plasma protein binding. Also examined is how albumin, α-1-acid glycoprotein, drug fraction unbound in plasma, CYP content, and oral clearance can change dynamically with time in response to inflammation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Enzimático do Citocromo P-450
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Inflamação
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article