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A chemically stable fluorescent marker of the ureter.
Cha, Jaepyeong; Nani, Roger R; Luciano, Michael P; Kline, Gabriel; Broch, Aline; Kim, Kihoon; Namgoong, Jung-Man; Kulkarni, Rhushikesh A; Meier, Jordan L; Kim, Peter; Schnermann, Martin J.
Afiliação
  • Cha J; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, 111 Michigan Ave., NW Washinton, DC 20010, United States. Electronic address: JCHA2@childrensnational.org.
  • Nani RR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Luciano MP; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Kline G; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Broch A; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, 111 Michigan Ave., NW Washinton, DC 20010, United States.
  • Kim K; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, 111 Michigan Ave., NW Washinton, DC 20010, United States; Department of Surgery, Inje University Haeundae Paik Hospital, 875 Haeun-daero, Haeundae-gu, Busan 612-896, South Korea.
  • Namgoong JM; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, 111 Michigan Ave., NW Washinton, DC 20010, United States; Department of Surgery, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, South Korea.
  • Kulkarni RA; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Meier JL; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Kim P; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, 111 Michigan Ave., NW Washinton, DC 20010, United States.
  • Schnermann MJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States. Electronic address: martin.schnermann@nih.gov.
Bioorg Med Chem Lett ; 28(16): 2741-2745, 2018 09 01.
Article em En | MEDLINE | ID: mdl-29510880
Surgical methods guided by exogenous fluorescent markers have the potential to define tissue types in real time. Small molecule dyes with efficient and selective renal clearance could enable visualization of the ureter during surgical procedures involving the abdomen and pelvis. These studies report the design and synthesis of a water soluble, net neutral C4'-O-alkyl heptamethine cyanine, Ureter-Label (UL)-766, with excellent properties for ureter visualization. This compound is accessed through a concise synthetic sequence involving an N- to O-transposition reaction that provides other inaccessible C4'-O-alkyl heptamethine cyanines. Unlike molecules containing a C4'-O-aryl substituent, which have also been used for ureter visualization, UL-766 is not reactive towards glutathione and the cellular proteome. In addition, rat models of abdominal surgery reveal that UL-766 undergoes efficient and nearly exclusive renal clearance in vivo. In total, this molecule represents a promising candidate for visualizing the ureter during a variety of surgical interventions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ureter / Corantes Fluorescentes Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ureter / Corantes Fluorescentes Idioma: En Ano de publicação: 2018 Tipo de documento: Article