Controlling the activity of quorum sensing autoinducers with light.
Chem Sci
; 6(6): 3593-3598, 2015 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-29511521
ABSTRACT
Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.
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MEDLINE
Idioma:
En
Ano de publicação:
2015
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Article