Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra.

Grames, Mychal S; Dayton, Robert D; Jackson, Kasey L; Richard, Adam D; Lu, Xiaohong; Klein, Ronald L

Grames, Mychal S; Dayton, Robert D; Jackson, Kasey L; Richard, Adam D; Lu, Xiaohong; Klein, Ronald L.

Afiliação

Grames MS; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University (LSU) Health Shreveport, Shreveport, Louisiana, USA.
Dayton RD; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University (LSU) Health Shreveport, Shreveport, Louisiana, USA.
Jackson KL; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University (LSU) Health Shreveport, Shreveport, Louisiana, USA.
Richard AD; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University (LSU) Health Shreveport, Shreveport, Louisiana, USA.
Lu X; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University (LSU) Health Shreveport, Shreveport, Louisiana, USA.
Klein RL; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University (LSU) Health Shreveport, Shreveport, Louisiana, USA.

FASEB J ; 32(8): 4420-4427, 2018 08.

Article em En | MEDLINE | ID: mdl-29513569

Assuntos

Dependovirus/metabolismo; Vetores Genéticos/metabolismo; Integrases/metabolismo; Doenças Neurodegenerativas/metabolismo; Substância Negra/metabolismo; Animais; Modelos Animais de Doenças; Neurônios Dopaminérgicos/metabolismo; Feminino; Ratos; alfa-Sinucleína/metabolismo

Palavras-chave

TDP-43; adeno-associated virus; pathological protein spreading; tau; α-synuclein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substância Negra / Dependovirus / Integrases / Doenças Neurodegenerativas / Vetores Genéticos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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