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Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes.
Echeverri, Marcelo; Alvarez-Valdés, Amparo; Navas, Francisco; Perles, Josefina; Sánchez-Pérez, Isabel; Quiroga, A G.
Afiliação
  • Echeverri M; Inorganic Chemistry Department, Universidad Autónoma de Madrid, Madrid, Spain.
  • Alvarez-Valdés A; Inorganic Chemistry Department, Universidad Autónoma de Madrid, Madrid, Spain.
  • Navas F; Inorganic Chemistry Department, Universidad Autónoma de Madrid, Madrid, Spain.
  • Perles J; Single Crystal XRD Laboratory, SIdI, Universidad Autónoma de Madrid, Madrid, Spain.
  • Sánchez-Pérez I; Instituto de Investigaciones Biomédicas Albert Sols, Madrid, Spain.
  • Quiroga AG; Inorganic Chemistry Department, Universidad Autónoma de Madrid, Madrid, Spain.
R Soc Open Sci ; 5(2): 171340, 2018 Feb.
Article em En | MEDLINE | ID: mdl-29515851
ABSTRACT
Three platinum complexes with cis and trans configuration cis-[Pt(TCEP)2Cl2], cis-[Pt(tmTCEP)2Cl2] and trans-[Pt(TCEP)2Cl2], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP)2Cl2] and cis-[Pt(tmTCEP)2Cl2]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article