Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR.
Magn Reson Chem
; 56(10): 969-975, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-29520830
ABSTRACT
Recent developments in data sampling and processing techniques have made it possible to acquire 2-dimensional NMR spectra of small molecules at digital resolutions in both dimensions approaching the intrinsic limitations of the equipment and sample on a realistic timescale. These developments offer the possibility of enormously increased effective resolution (peak dispersion) and the ability to effectively study samples where peak overlap was previously a limiting factor. Examples of such spectra have been produced for a number of 2-dimensional techniques including TOCSY and HSQC. In this paper, we investigate some of the problems in applying such techniques to COSY spectra and suggest a modification to the classic experiment that alleviates some of these problems.
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MEDLINE
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En
Ano de publicação:
2018
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Article