A Review of the Current Evidence on Gadolinium Deposition in the Brain.
Clin Neuroradiol
; 28(2): 159-169, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29523896
ABSTRACT
Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Imageamento por Ressonância Magnética
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Gadolínio
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article