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Extracellular matrix in lung development, homeostasis and disease.
Zhou, Yong; Horowitz, Jeffrey C; Naba, Alexandra; Ambalavanan, Namasivayam; Atabai, Kamran; Balestrini, Jenna; Bitterman, Peter B; Corley, Richard A; Ding, Bi-Sen; Engler, Adam J; Hansen, Kirk C; Hagood, James S; Kheradmand, Farrah; Lin, Qing S; Neptune, Enid; Niklason, Laura; Ortiz, Luis A; Parks, William C; Tschumperlin, Daniel J; White, Eric S; Chapman, Harold A; Thannickal, Victor J.
Afiliação
  • Zhou Y; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, United States. Electronic address: yongzhou@uabmc.edu.
  • Horowitz JC; Division of Pulmonary and Critical Care Medicine, University of Michigan, United States. Electronic address: jchorow@med.umich.edu.
  • Naba A; Department of Physiology & Biophysics, University of Illinois at Chicago, United States. Electronic address: anaba@uic.edu.
  • Ambalavanan N; Department of Pediatrics, University of Alabama at Birmingham, United States. Electronic address: nambalavanan@peds.uab.edu.
  • Atabai K; Lung Biology Center, University of California, San Francisco, United States. Electronic address: Kamran.Atabai@ucsf.edu.
  • Balestrini J; Department of Anesthesiology, Yale University, United States. Electronic address: jenna.balestrini@yale.edu.
  • Bitterman PB; Department of Medicine, University of Minnesota, United States. Electronic address: bitte001@umn.edu.
  • Corley RA; Systems Toxicology & Exposure Science, Pacific Northwest National Laboratory, United States. Electronic address: rick.corley@pnnl.gov.
  • Ding BS; Weill Cornell Medical College, United States. Electronic address: bid2004@med.cornell.edu.
  • Engler AJ; Sanford Consortium for Regenerative Medicine, University of California, San Diego, United States. Electronic address: aengler@eng.ucsd.edu.
  • Hansen KC; Biochemistry & Molecular Genetics, University of Colorado Denver, United States. Electronic address: Kirk.Hansen@ucdenver.edu.
  • Hagood JS; Pediatric Respiratory Medicine, University of California San Diego, United States. Electronic address: jhagood@ucsd.edu.
  • Kheradmand F; Division of Pulmonary and Critical Care, Baylor College of Medicine, United States. Electronic address: farrahk@bcm.tmc.edu.
  • Lin QS; Division of Lung Diseases, National Heart, Lung, and Blood Institute, United States. Electronic address: Sara.lin@nih.gov.
  • Neptune E; Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, United States. Electronic address: eneptune@jhmi.edu.
  • Niklason L; Department of Anesthesiology, Yale University, United States. Electronic address: laura.niklason@yale.edu.
  • Ortiz LA; Division of Environmental and Occupational Health, University of Pittsburgh, United States. Electronic address: lao1@pitt.edu.
  • Parks WC; Department of Medicine, Cedars-Sinai Medical Center, United States. Electronic address: bill.parks@cshs.org.
  • Tschumperlin DJ; Department of Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, United States. Electronic address: Tschumperlin.Daniel@mayo.edu.
  • White ES; Division of Pulmonary and Critical Care Medicine, University of Michigan, United States. Electronic address: docew@med.umich.edu.
  • Chapman HA; Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, United States. Electronic address: Hal.Chapman@ucsf.edu.
  • Thannickal VJ; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, United States. Electronic address: vthannickal@uabmc.edu.
Matrix Biol ; 73: 77-104, 2018 11.
Article em En | MEDLINE | ID: mdl-29524630
ABSTRACT
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Matriz Extracelular / Pulmão / Pneumopatias Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Matriz Extracelular / Pulmão / Pneumopatias Idioma: En Ano de publicação: 2018 Tipo de documento: Article