Differential prevalence and demographic and clinical correlates of antidepressant use in American bipolar I versus bipolar II disorder patients.
J Affect Disord
; 234: 74-79, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29524749
ABSTRACT
AIMS:
Antidepressant use is controversial in bipolar disorder (BD) due to questionable efficacy/psychiatric tolerability. We assessed demographic/clinical characteristics of baseline antidepressant use in BD patients.METHODS:
Prevalence and correlates of baseline antidepressant use in 503 BD I and BD II outpatients referred to the Stanford Bipolar Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation.RESULTS:
Antidepressant use was 39.0%, overall, and was higher in BD II versus BD I (46.9% versus 30.5%, pâ¯=â¯0.0002). Both BD I and BD II antidepressant compared to non-antidepressant users had higher rates of complex pharmacotherapy (≥â¯4 mood stabilizers, antipsychotics, and/or antidepressants) and use of other psychotropics. Antidepressant use in BD II versus BD I was higher during euthymia (44.0% vs. 28.0%) and subsyndromal symptoms (56.1% vs. 28.6%), but not depression or mood elevation.LIMITATIONS:
American tertiary BD clinic referral sample receiving open naturalistic treatment.CONCLUSIONS:
In our sample, antidepressant use was higher in BD II versus BD I patients, and was associated with markers of heightened illness severity in both BD I and BD II patients. Additional research is warranted to investigate these complex relationships.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Demografia
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Preferência do Paciente
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Antidepressivos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article