S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NF&#954;B signalling.

Dong, Yin-Feng; Guo, Ruo-Bing; Ji, Juan; Cao, Lu-Lu; Zhang, Ling; Chen, Zheng-Zhen; Huang, Ji-Ye; Wu, Jin; Lu, Jun; Sun, Xiu-Lan

S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling.

Dong, Yin-Feng; Guo, Ruo-Bing; Ji, Juan; Cao, Lu-Lu; Zhang, Ling; Chen, Zheng-Zhen; Huang, Ji-Ye; Wu, Jin; Lu, Jun; Sun, Xiu-Lan.

Afiliação

Dong YF; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Guo RB; School of Nursing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Ji J; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Cao LL; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Zhang L; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Chen ZZ; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Huang JY; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Wu J; Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Lu J; Department of Internal Neurology, the Second Affiliated Hospital, Nanjing, Jiangsu, China.
Sun XL; College of Health Sciences, Jiangsu Normal University, Xuzhou, Jiangsu, China.

J Cell Mol Med ; 22(6): 3159-3166, 2018 06.

Article em En | MEDLINE | ID: mdl-29536648

Assuntos

Cloridrato de Fingolimode/farmacologia; Inflamação/tratamento farmacológico; Receptores de Lisoesfingolipídeo/genética; Receptor 2 Toll-Like/genética; Receptor 4 Toll-Like/genética; Animais; Astrócitos/efeitos dos fármacos; Carência Cultural; Citocinas/genética; Modelos Animais de Doenças; Cloridrato de Fingolimode/química; Proteína HMGB1/genética; Humanos; Imunossupressores/química; Imunossupressores/farmacologia; Inflamação/genética; Inflamação/patologia; NF-kappa B/genética; Fosfatidilinositol 3-Quinases/genética; Fosforilação; Cultura Primária de Células; Ratos; Receptores de Lisoesfingolipídeo/química; Transdução de Sinais/efeitos dos fármacos; Receptores de Esfingosina-1-Fosfato; Fator de Necrose Tumoral alfa/genética

Palavras-chave

astrocyte; fingolimod; neuroinflammation; sphingosine-1-phosphate receptor 3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Lisoesfingolipídeo / Receptor 2 Toll-Like / Receptor 4 Toll-Like / Cloridrato de Fingolimode / Inflamação Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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