New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines.
Arch Pharm Res
; 41(4): 431-437, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29546611
ABSTRACT
Three new limonoids, limonophyllines A-C (1, 4 and 5), along with two known limonoids (2 and 3) and 11 acridone alkaloids (6-16) were isolated from the stems of Atalantia monophylla. All isolates were evaluated against cholangiocarcinoma, KKU-M156, and HepG2 cancer cell lines. Compounds 12, 14 and 16 displayed cytotoxicity against KKU-M156 cell line with IC50 ranging from 3.39 to 4.1 µg/mL while cytotoxicity against HepG2 cell line with IC50 ranging from 1.43 to 8.4 µg/mL. The structures of all isolated compounds were established by spectroscopic methods including 1D and 2D NMR, IR and mass spectrometry.
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Base de dados:
MEDLINE
Assunto principal:
Colangiocarcinoma
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Rutaceae
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Citotoxinas
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Limoninas
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article