WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete.
Org Lett
; 20(7): 1999-2002, 2018 04 06.
Article
em En
| MEDLINE
| ID: mdl-29557658
ABSTRACT
WS9326H (1), a new cyclic peptide, was isolated from a mudflat-derived Streptomyces strain. Based on analysis by 1D/2D NMR, UV spectroscopy, and mass spectrometry, compound 1 was determined to have the gross structure of a cyclic heptapeptide bearing an unprecedented pyrazolone ring connected to a d-arabinitol via an amide bond. The absolute configuration of 1 was established by multistep chemical derivatizations, comprehensive NMR, and LC/MS analyses of the derivatives and quantum mechanics-based computational methods. WS9326H (1) displayed significant antiangiogenesis activity.
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Base de dados:
MEDLINE
Assunto principal:
Actinobacteria
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article