Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder.
Biol Psychiatry
; 83(10): 849-865, 2018 05 15.
Article
em En
| MEDLINE
| ID: mdl-29559087
ABSTRACT
Posttraumatic stress disorder (PTSD) is a pathologic response to trauma that impacts â¼8% of the population and is highly comorbid with other disorders, such as traumatic brain injury. PTSD affects multiple biological systems throughout the body, including the hypothalamic-pituitary-adrenal axis, cortical function, and the immune system, and while the study of the biological underpinnings of PTSD and related disorders are numerous, the roles of noncoding RNAs (ncRNAs) are just emerging. Moreover, deep sequencing has revealed that ncRNAs represent most of the transcribed mammalian genome. Here, we present developing evidence that ncRNAs are involved in critical aspects of PTSD pathophysiology. In that regard, we summarize the roles of three classes of ncRNAs in PTSD and related disorders microRNAs, long-noncoding RNAs, and retrotransposons. This review evaluates findings from both animal and human studies with a special focus on the role of ncRNAs in hypothalamic-pituitary-adrenal axis abnormalities and glucocorticoid dysfunction in PTSD and traumatic brain injury. We conclude that ncRNAs may prove to be useful biomarkers to facilitate personalized medicines for trauma-related brain disorders.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transtornos de Estresse Pós-Traumáticos
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Estresse Psicológico
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RNA não Traduzido
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Glucocorticoides
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article