Occurrence of neoplasms in individuals with congenital, severe GH deficiency from the Itabaianinha kindred.
Growth Horm IGF Res
; 41: 71-74, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29571594
ABSTRACT
Growth hormone (GH) and the insulin-like growth factor I (IGF-I) have cell proliferative and differentiation properties. Whether these hormones have a role in mutagenesis is unknown. Nevertheless, severe IGF-I deficiency seems to confer protection against the development of neoplasms. Here, we report five cases of adult patients with severe and congenital isolated GH deficiency (IGHD) due to the c.57+1G>A mutation in the GHRH receptor gene, who developed tumors. Four GH-naïve subjects presented skin tumors a 42-year-old man with a fibroepithelial polyp, a 53-year-old woman and two men (59 and 56â¯years old) with epidermoid skin cancers. One of these died from it after three surgeries and radiotherapy. The fifth patient was a 25-year-old woman, who had intermittently received GH replacement therapy (GHRT) from age 11 to 18, who developed an ependymoma extending from the fourth ventricle to the end of the thoracic spine. She underwent three surgical procedures, without obvious evidence of tumor recurrence during the six years follow up. These observations suggest that severe IGHD does not protect completely from development of tumors.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Receptores de Hormônios Reguladores de Hormônio Hipofisário
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Receptores de Neuropeptídeos
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Hormônio do Crescimento Humano
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Nanismo Hipofisário
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Mutação
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Neoplasias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article