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Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis.
Deng, S; Lei, W; de Hoog, G S; Yang, L; Vitale, R G; Rafati, H; Seyedmousavi, M; Tolooe, A; van der Lee, H; Liao, W; Verweij, P E; Seyedmousavi, S.
Afiliação
  • Deng S; Department of Medical Microbiology, People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Jiangsu, China.
  • Lei W; Shanghai Institute of Medical Mycology, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
  • de Hoog GS; Shanghai Institute of Medical Mycology, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
  • Yang L; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
  • Vitale RG; Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil.
  • Rafati H; Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
  • Seyedmousavi M; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
  • Tolooe A; CONICET and Ramos Mejia Hospital, Parasitology Unit, Mycology Section, Buenos Aires, Argentina.
  • van der Lee H; Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran.
  • Liao W; Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran.
  • Verweij PE; Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran.
  • Seyedmousavi S; Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
Antimicrob Agents Chemother ; 62(6)2018 06.
Article em En | MEDLINE | ID: mdl-29581111
ABSTRACT
Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii, Cladophialophora arxii, Exophialadermatitidis, Exophialaspinifera, Fonsecaea monophora, Fonsecaea nubica, Fonsecaea pedrosoi, and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anfotericina B / Cromoblastomicose / Terbinafina / Antifúngicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anfotericina B / Cromoblastomicose / Terbinafina / Antifúngicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article