LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.
Proc Natl Acad Sci U S A
; 115(15): 3948-3953, 2018 04 10.
Article
em En
| MEDLINE
| ID: mdl-29581259
ABSTRACT
Long-term potentiation (LTP) is a persistent strengthening of synaptic transmission in the brain and is arguably the most compelling cellular and molecular model for learning and memory. Previous work found that both AMPA receptors and exogenously expressed kainate receptors are equally capable of expressing LTP, despite their limited homology and their association with distinct auxiliary subunits, indicating that LTP is far more promiscuous than previously thought. What might these two subtypes of glutamate receptor have in common? Using a single-cell molecular replacement strategy, we demonstrate that the AMPA receptor auxiliary subunit TARP γ-8, via its PDZ-binding motif, is indispensable for both basal synaptic transmission and LTP. Remarkably, kainate receptors and their auxiliary subunits Neto proteins share the same requirement of PDZ-binding domains for synaptic trafficking and LTP. Together, these results suggest that a minimal postsynaptic requirement for LTP is the PDZ binding of glutamate receptors/auxiliary subunits to PSD scaffolding proteins.
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Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Canais de Cálcio
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Receptores de AMPA
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Potenciação de Longa Duração
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article