SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
Autoimmunity
; 51(3): 96-110, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29583030
ABSTRACT
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi-Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor for retroviruses, such as HIV. Here, we review the current biochemical and biological properties of the enzyme including its structure, activity, and regulation by post-translational modifications in the context of its cellular function. We outline open questions regarding the biology of SAMHD1 whose answers will be important for understanding its function as a regulator of cell cycle progression, genomic integrity, and in autoimmunity.
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MEDLINE
Assunto principal:
Autoimunidade
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Ciclo Celular
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Doenças Autoimunes do Sistema Nervoso
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Proteína 1 com Domínio SAM e Domínio HD
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Imunidade Inata
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Neoplasias
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Malformações do Sistema Nervoso
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article