Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla.
Mar Drugs
; 16(4)2018 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-29587405
ABSTRACT
A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (4-7 and 10). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds (8 and 9) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity.
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Base de dados:
MEDLINE
Assunto principal:
Antozoários
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Diterpenos
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Proteína Tirosina Fosfatase não Receptora Tipo 1
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article