The Aß protofibril selective antibody mAb158 prevents accumulation of Aß in astrocytes and rescues neurons from Aß-induced cell death.

Söllvander, Sofia; Nikitidou, Elisabeth; Gallasch, Linn; Zysk, Marlena; Söderberg, Linda; Sehlin, Dag; Lannfelt, Lars; Erlandsson, Anna

Söllvander, Sofia; Nikitidou, Elisabeth; Gallasch, Linn; Zysk, Marlena; Söderberg, Linda; Sehlin, Dag; Lannfelt, Lars; Erlandsson, Anna.

Afiliação

Söllvander S; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Nikitidou E; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Gallasch L; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Zysk M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Söderberg L; BioArctic AB, Warfvinges väg 35, SE-112 51, Stockholm, Sweden.
Sehlin D; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Lannfelt L; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Erlandsson A; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. anna.erlandsson@pubcare.uu.se.

J Neuroinflammation ; 15(1): 98, 2018 Mar 28.

Article em En | MEDLINE | ID: mdl-29592816

Assuntos

Proteínas Amiloidogênicas; Anticorpos Monoclonais/farmacologia; Morte Celular/efeitos dos fármacos; Neuroglia/efeitos dos fármacos; Neurônios/efeitos dos fármacos; Proteínas Amiloidogênicas/imunologia; Proteínas Amiloidogênicas/metabolismo; Proteínas Amiloidogênicas/farmacologia; Animais; Células Cultivadas; Córtex Cerebral/citologia; Técnicas de Cocultura; Lisossomos/efeitos dos fármacos; Lisossomos/metabolismo; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

Alzheimer's disease; Amyloid-ß; Antibody; Astrocyte; Clearance; Neuron

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neuroglia / Morte Celular / Proteínas Amiloidogênicas / Anticorpos Monoclonais / Neurônios Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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