Synthesis and antitumor, antityrosinase, and antioxidant activities of xanthone.
J Asian Nat Prod Res
; 20(5): 467-476, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29597932
ABSTRACT
Ten substituted 1,3-dihydroxyxanthones were synthesized in one step. The yields ranged from 40 to 76%. Compounds 8-10 were first reported. Next, the compounds' in vitro anti-proliferative activities against nine human cancer cell lines, antityrosinase, and antioxidant activities were evaluated. Compounds 1, 4, 6-7, and 9-10 exhibited enhanced cytotoxicity against certain cancer cells. Compounds 2, 8, 9, and 10 inhibited tyrosinase activity to a certain extent. In addition, compound 4 exhibited the best antioxidant activity, which was consistent with theoretical calculations. These results demonstrated that compounds 1-2, 4, and 6-10 were promising leads for further investigation.
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Base de dados:
MEDLINE
Assunto principal:
Monofenol Mono-Oxigenase
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Xantonas
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Antineoplásicos
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Antioxidantes
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article