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Evaluation of the intracellular activity of drugs against Mycobacterium abscessus using a THP-1 macrophage model.
Molina-Torres, Carmen Amelia; Tamez-Peña, Lorena; Castro-Garza, Jorge; Ocampo-Candiani, Jorge; Vera-Cabrera, Lucio.
Afiliação
  • Molina-Torres CA; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico. Electronic address: carmelia7@hotmail.com.
  • Tamez-Peña L; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico.
  • Castro-Garza J; Centro de Investigación Biomédica del Noreste, IMSS, Monterrey, N.L., Mexico.
  • Ocampo-Candiani J; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico.
  • Vera-Cabrera L; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico.
J Microbiol Methods ; 148: 29-32, 2018 05.
Article em En | MEDLINE | ID: mdl-29626567
ABSTRACT
We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Macrófagos / Antibacterianos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Macrófagos / Antibacterianos Idioma: En Ano de publicação: 2018 Tipo de documento: Article