Longer diabetes duration reduces myocardial blood flow in remote myocardium assessed by dynamic myocardial CT perfusion.
J Diabetes Complications
; 32(6): 609-615, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29627375
ABSTRACT
AIMS:
To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion. MATERIALS ANDMETHODS:
We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis.RESULTS:
A weak but significantly negative relationship was present between diabetes duration and MBF (R2â¯=â¯0.05, pâ¯<â¯0.01). The average MBF of patients with a duration of >8â¯years was 13% lower than that of the remaining patients (1.11⯱â¯0.35 vs 1.28⯱â¯0.27â¯mlâ¯min-1â¯g-1, pâ¯<â¯0.01). Duration of one year was associated with a 6% increased risk for low MBF (<1.18â¯mlâ¯min-1â¯g-1) (odds ratio 1.06, 95% confidence interval 1.01-1.12, pâ¯<â¯0.05). Calcium score was also a significant factor for low MBF (odds ratio 1.08 (per 100 Agatston units), 95% confidence interval 1.01-1.17, pâ¯<â¯0.05).CONCLUSION:
Longer diabetes duration is associated with lower MBF independent of conventional cardiac risk factors or the presence of coronary stenosis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Circulação Coronária
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Estenose Coronária
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Diabetes Mellitus Tipo 2
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Coração
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article