The synthesis of a new unsaturated derivative of chondroitin sulfate with increased antioxidant properties.
Carbohydr Polym
; 190: 175-183, 2018 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-29628235
ABSTRACT
Chondroitin sulfate (CS) was regio-specifically modified to an unsaturated derivative (ΔCS) with a double bond in positions 4 and 5 of N-acetyl-d-galactosamine. The structure of ΔCS was elucidated in detail by two dimensional nuclear magnetic resonance, ultraviolet spectroscopy and mass spectrometry. The introduction of a nucleophilic CC double bond into a polymer backbone had no influence on biocompatibility of CS, which was demonstrated by MTT live-dead assay and enzymatic degradation in vitro. On the other hand the chemical modification significantly enhanced the reactivity of ΔCS towards numerous oxidizing agents, which might be promising for a variety of biomedical and cosmetic applications.
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Base de dados:
MEDLINE
Assunto principal:
Sulfatos de Condroitina
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Sequestradores de Radicais Livres
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article