BPA exposure is associated with non-monotonic alteration in ESR1 promoter methylation in peripheral blood of men and shorter relative telomere length in peripheral blood of women.
J Expo Sci Environ Epidemiol
; 29(1): 118-128, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-29643374
ABSTRACT
The aim of this study was to evaluate the potential association of urinary Bisphenol A (BPA) levels with estrogen receptor alpha (ESR1) promoter % methylation and relative telomere length in a sample of 482 participants. Urinary BPA concentration was measured using organic phase extraction followed by high performance liquid chromatography mass spectroscopy. Peripheral blood ESR1 promoter % methylation and relative telomere length were measured using direct bisulfite sequencing and real-time polymerase chain reaction, respectively. The mean ± SD urinary BPA concentration adjusted for urinary creatinine was 2.90 ± 4.81 (µg/g creatinine) with a median of 1.86 µg/g creatinine (min-max Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
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Compostos Benzidrílicos
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Telômero
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Receptor alfa de Estrogênio
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Poluentes Ambientais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article