A Randomized Placebo-Controlled Cross-Over Pilot Study of Riluzole for Drug-Refractory Irritability in Autism Spectrum Disorder.

Wink, Logan K; Adams, Ryan; Horn, Paul S; Tessier, Charles R; Bantel, Andrew P; Hong, Michael; Shaffer, Rebecca C; Pedapati, Ernest V; Erickson, Craig A

Wink, Logan K; Adams, Ryan; Horn, Paul S; Tessier, Charles R; Bantel, Andrew P; Hong, Michael; Shaffer, Rebecca C; Pedapati, Ernest V; Erickson, Craig A.

Afiliação

Wink LK; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA. logan.wink@cchmc.org.
Adams R; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.
Horn PS; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.
Tessier CR; Indiana University School of Medicine, Indianapolis, IN, USA.
Bantel AP; Indiana University School of Medicine, Indianapolis, IN, USA.
Hong M; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.
Shaffer RC; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.
Pedapati EV; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.
Erickson CA; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.

J Autism Dev Disord ; 48(9): 3051-3060, 2018 Sep.

Article em En | MEDLINE | ID: mdl-29644582

Assuntos

Transtorno do Espectro Autista/tratamento farmacológico; Transtorno do Espectro Autista/psicologia; Antagonistas de Aminoácidos Excitatórios/uso terapêutico; Humor Irritável/efeitos dos fármacos; Riluzol/uso terapêutico; Adolescente; Adulto; Transtorno do Espectro Autista/diagnóstico; Criança; Estudos Cross-Over; Método Duplo-Cego; Antagonistas de Aminoácidos Excitatórios/farmacologia; Feminino; Humanos; Humor Irritável/fisiologia; Masculino; Projetos Piloto; Riluzol/farmacologia; Resultado do Tratamento; Adulto Jovem

Palavras-chave

Autism; Autism spectrum disorder; ERK; Extracellular signal related kinase; Irritability; Riluzole

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Humor Irritável / Antagonistas de Aminoácidos Excitatórios / Riluzol / Transtorno do Espectro Autista Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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