Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive ß-F elimination and C-F bond activation.
Chem Commun (Camb)
; 54(35): 4406-4409, 2018 Apr 26.
Article
em En
| MEDLINE
| ID: mdl-29645026
ABSTRACT
An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive ß-F elimination and C-F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by C-F bond activation.
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MEDLINE
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En
Ano de publicação:
2018
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Article