Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins.

Martin, Esther M; Jackson, Matthew P; Gamerdinger, Martin; Gense, Karina; Karamonos, Theodoros K; Humes, Julia R; Deuerling, Elke; Ashcroft, Alison E; Radford, Sheena E

Martin, Esther M; Jackson, Matthew P; Gamerdinger, Martin; Gense, Karina; Karamonos, Theodoros K; Humes, Julia R; Deuerling, Elke; Ashcroft, Alison E; Radford, Sheena E.

Afiliação

Martin EM; From the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and.
Jackson MP; From the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and.
Gamerdinger M; the Department of Biology, Institute of Molecular Microbiology, University of Konstanz, 78454 Konstanz, Germany.
Gense K; the Department of Biology, Institute of Molecular Microbiology, University of Konstanz, 78454 Konstanz, Germany.
Karamonos TK; From the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and.
Humes JR; From the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and.
Deuerling E; the Department of Biology, Institute of Molecular Microbiology, University of Konstanz, 78454 Konstanz, Germany.
Ashcroft AE; From the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and.
Radford SE; From the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and s.e.radford@leeds.ac.uk.

J Biol Chem ; 293(22): 8554-8568, 2018 06 01.

Article em En | MEDLINE | ID: mdl-29650757

Assuntos

Proteínas de Caenorhabditis elegans/química; Caenorhabditis elegans/metabolismo; Chaperonas Moleculares/química; Peptídeos/metabolismo; Biossíntese de Proteínas; Sinucleínas/química; Animais; Proteínas de Caenorhabditis elegans/metabolismo; Cristalografia por Raios X; Chaperonas Moleculares/metabolismo; Peptídeos/química; Ligação Proteica; Dobramento de Proteína; Domínios e Motivos de Interação entre Proteínas; Sinucleínas/metabolismo

Palavras-chave

NAC native mass spectrometry (MS); chaperone; molecular chaperone; nuclear magnetic resonance (NMR); protein cross-linking; protein folding; protein misfolding

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Biossíntese de Proteínas / Caenorhabditis elegans / Chaperonas Moleculares / Proteínas de Caenorhabditis elegans / Sinucleínas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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