Intrarenal delivery of bFGF-loaded liposome under guiding of ultrasound-targeted microbubble destruction prevent diabetic nephropathy through inhibition of inflammation.

Sheng, Wen-Shuang; Xu, He-Lin; Zheng, Lei; Zhuang, Yuan-Di; Jiao, Li-Zhuo; Zhou, Jia-Feng; ZhuGe, De-Li; Chi, Ting-Ting; Zhao, Ying-Zheng; Lan, Li

Sheng, Wen-Shuang; Xu, He-Lin; Zheng, Lei; Zhuang, Yuan-Di; Jiao, Li-Zhuo; Zhou, Jia-Feng; ZhuGe, De-Li; Chi, Ting-Ting; Zhao, Ying-Zheng; Lan, Li.

Afiliação

Sheng WS; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Xu HL; b School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Zheng L; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Zhuang YD; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Jiao LZ; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Zhou JF; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
ZhuGe DL; b School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Chi TT; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Zhao YZ; b School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
Lan L; a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.

Artif Cells Nanomed Biotechnol ; 46(sup2): 373-385, 2018.

Article em En | MEDLINE | ID: mdl-29653493

Assuntos

Nefropatias Diabéticas/prevenção & controle; Fator 2 de Crescimento de Fibroblastos/administração & dosagem; Fator 2 de Crescimento de Fibroblastos/farmacologia; Rim/metabolismo; Microbolhas; Ondas Ultrassônicas; Animais; Caspase 3/metabolismo; Quimiocina CCL2/metabolismo; Nefropatias Diabéticas/metabolismo; Fator 2 de Crescimento de Fibroblastos/metabolismo; Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos; Inflamação/tratamento farmacológico; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Lipossomos; Masculino; Proteínas de Membrana/metabolismo; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Ratos; Ratos Sprague-Dawley; Fator de Crescimento Transformador beta1/metabolismo; Proteína X Associada a bcl-2/metabolismo

Palavras-chave

Diabetic nephropathy; basic fibroblast growth factor; inflammation; liposome; ultrasound-targeted microbubble destruction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 de Crescimento de Fibroblastos / Microbolhas / Nefropatias Diabéticas / Ondas Ultrassônicas / Rim Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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