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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
Bergmeijer, Thomas O; Reny, Jean-Luc; Pakyz, Ruth E; Gong, Li; Lewis, Joshua P; Kim, Eun-Young; Aradi, Daniel; Fernandez-Cadenas, Israel; Horenstein, Richard B; Lee, Ming Ta Michael; Whaley, Ryan M; Montaner, Joan; Gensini, Gian Franco; Cleator, John H; Chang, Kiyuk; Holmvang, Lene; Hochholzer, Willibald; Roden, Dan M; Winter, Stefan; Altman, Russ B; Alexopoulos, Dimitrios; Kim, Ho-Sook; Déry, Jean-Pierre; Gawaz, Meinrad; Bliden, Kevin; Valgimigli, Marco; Marcucci, Rossella; Campo, Gianluca; Schaeffeler, Elke; Dridi, Nadia P; Wen, Ming-Shien; Shin, Jae Gook; Simon, Tabassome; Fontana, Pierre; Giusti, Betti; Geisler, Tobias; Kubo, Michiaki; Trenk, Dietmar; Siller-Matula, Jolanta M; Ten Berg, Jurriën M; Gurbel, Paul A; Hulot, Jean-Sebastien; Mitchell, Braxton D; Schwab, Matthias; Ritchie, Marylyn DeRiggi; Klein, Teri E; Shuldiner, Alan R.
Afiliação
  • Bergmeijer TO; St Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands.
  • Reny JL; Internal Medicine, Béziers Hospital, France, Geneva Platelet Group, University of Geneva School of Medicine, Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
  • Pakyz RE; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Gong L; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
  • Lewis JP; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Kim EY; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea.
  • Aradi D; Heart Center Balatonfüred and Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Fernandez-Cadenas I; Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Neurovascular Research Laboratory, Valle d'Hebron Hebron Institute of Research, Barcelona, Spain.
  • Horenstein RB; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Lee MTM; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
  • Whaley RM; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
  • Montaner J; Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Barcelona, Spain.
  • Gensini GF; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Cleator JH; Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Chang K; Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Holmvang L; Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Hochholzer W; University Heart Center Freiburg, Bad Krozingen, Department of Cardiology and Angiology II, Bad Krozingen, Germany.
  • Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Winter S; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany.
  • Altman RB; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Departments of Bioengineering and Genetics, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Alexopoulos D; Department of Cardiology, Patras University Hospital, Patras, Greece.
  • Kim HS; Department of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea.
  • Déry JP; Quebec Heart and Lung Institute, Québec, Canada.
  • Gawaz M; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.
  • Bliden K; Inova Center for Thrombosis Research and Drug Development. Inova Heart and Vascular Institute, Falls Church, VA, USA.
  • Valgimigli M; Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland.
  • Marcucci R; Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
  • Campo G; Cardiology Unit, Azienda Ospedaliera Universitria di Ferrara, Cona (FE) and Maria Cecilia Hospital, GVM Care and Research, Cotignola, (RA), Italy.
  • Schaeffeler E; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany.
  • Dridi NP; Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Wen MS; Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou and School of Medicine, Chang Gung University, Taoyuan City, Taiwan.
  • Shin JG; Department of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea.
  • Simon T; APHP, Saint Antoine Hospital, Paris, France.
  • Fontana P; Geneva Platelet Group, University of Geneva School of Medicine, Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland.
  • Giusti B; Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
  • Geisler T; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.
  • Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
  • Trenk D; Department of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.
  • Siller-Matula JM; Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  • Ten Berg JM; St Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands.
  • Gurbel PA; Inova Center for Thrombosis Research and Drug Development. Inova Heart and Vascular Institute, Falls Church, VA, USA.
  • Hulot JS; Sorbonne Universités, UPMC Univ Paris 06, Institute of Cardiometabolism and Nutrition (ICAN), Pitié-Salpêtrière Hospital, F-75013 Paris, France.
  • Mitchell BD; Department of Medicine, University of Maryland, Baltimore, MD, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, MD.
  • Schwab M; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany; Department of Clinical Pharmacology, University Hospital, Tübingen, Germany.
  • Ritchie MD; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA.
  • Klein TE; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Shuldiner AR; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: ashuldin@som.umaryland.edu.
Am Heart J ; 198: 152-159, 2018 04.
Article em En | MEDLINE | ID: mdl-29653637
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome Coronariana Aguda / Estudo de Associação Genômica Ampla / Receptores Purinérgicos P2Y12 / Terapia de Alvo Molecular / Clopidogrel Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome Coronariana Aguda / Estudo de Associação Genômica Ampla / Receptores Purinérgicos P2Y12 / Terapia de Alvo Molecular / Clopidogrel Idioma: En Ano de publicação: 2018 Tipo de documento: Article