Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes?
Hum Immunol
; 79(7): 532-536, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29660451
ABSTRACT
BACKGROUND:
Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes.METHODS:
The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease.RESULTS:
Of 66 donor-recipient pairs, 26(39.4%) were gamma-type matches, 34(51.5%) were mismatches, and 6(9.1%) were "indeterminate." Matching status was not associated with overall survival (pâ¯=â¯0.43), relapse (pâ¯=â¯0.21), acute GVHD (pâ¯=â¯0.43), severe aGVHD (pâ¯=â¯0.31), or chronic GVHD (pâ¯=â¯0.23) in univariate analyses, nor in multivariate analyses (pâ¯=â¯0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status.CONCLUSIONS:
In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
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Transplante de Células-Tronco
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Genótipo
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Antígenos HLA
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Complexo Principal de Histocompatibilidade
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article