Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies.

Nasr, Tamer; Bondock, Samir; Rashed, Hassan M; Fayad, Walid; Youns, Mahmoud; Sakr, Tamer M

Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies.

Nasr, Tamer; Bondock, Samir; Rashed, Hassan M; Fayad, Walid; Youns, Mahmoud; Sakr, Tamer M.

Afiliação

Nasr T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Modern University for Technology and Information, Egypt. Electronic address: tamerhefni@yahoo.com.
Bondock S; Department of Chemistry, Faculty of Science, Mansoura University, ET-35516, Mansoura, Egypt; Department of Chemistry, Faculty of Science, King Khalid University, 9004, Abha, Saudi Arabia.
Rashed HM; Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, P.O. Code 13759, Cairo, Egypt.
Fayad W; Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Youns M; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Egypt. Electronic address: dr.mahmoudyouns@yahoo.com.
Sakr TM; Radioactive Isotopes and Generators Department, Hot Laboratories Centre, Atomic Energy Authority, P.O. Code 13759, Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza, Egypt. Electronic address: Tamer_sakr78@yahoo.com.

Eur J Med Chem ; 151: 723-739, 2018 May 10.

Article em En | MEDLINE | ID: mdl-29665526

Assuntos

Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Cumarínicos/química; Cumarínicos/farmacologia; Hidrazonas/química; Hidrazonas/farmacologia; Animais; Antineoplásicos/síntese química; Antineoplásicos/farmacocinética; Linhagem Celular Tumoral; Cumarínicos/síntese química; Cumarínicos/farmacocinética; Citocromo P-450 CYP3A/metabolismo; Inibidores do Citocromo P-450 CYP3A/síntese química; Inibidores do Citocromo P-450 CYP3A/química; Inibidores do Citocromo P-450 CYP3A/farmacocinética; Inibidores do Citocromo P-450 CYP3A/farmacologia; Halogenação; Humanos; Hidrazonas/síntese química; Hidrazonas/farmacocinética; Camundongos; Neoplasias/tratamento farmacológico; Neoplasias/metabolismo; Neoplasias/patologia; Distribuição Tecidual

Palavras-chave

Apoptosis; CYP3A4; Caspases 3/7; Coumarin hydrazide-hydrazone; GST; Microarray; Radiolabeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Cumarínicos / Hidrazonas / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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