A randomized trial of normothermic preservation in liver transplantation.
Nature
; 557(7703): 50-56, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29670285
ABSTRACT
Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preservação de Órgãos
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Temperatura
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Transplante de Fígado
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Coleta de Tecidos e Órgãos
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Aloenxertos
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Fígado
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article