LPS Exposure in Early Life Protects Against Mucus Hypersecretion in Ovalbumin-Induced Asthma by Down-Regulation of the IL-13 and JAK-STAT6 Pathways.

Ding, Fengxia; Liu, Bo; Zou, Wenjing; Tian, Daiyin; Li, Qubei; Dai, Jihong; Luo, Zhengxiu; Fu, Zhou

Ding, Fengxia; Liu, Bo; Zou, Wenjing; Tian, Daiyin; Li, Qubei; Dai, Jihong; Luo, Zhengxiu; Fu, Zhou.

Afiliação

Ding F; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key
Liu B; Department of Urology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China.
Zou W; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key
Tian D; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key
Li Q; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key
Dai J; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key
Luo Z; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key
Fu Z; Department of Pediatric respiratory medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China International Science and Technology Cooperation base of Child development and Critical Disorders. Chongqing Key

Cell Physiol Biochem ; 46(3): 1263-1274, 2018.

Article em En | MEDLINE | ID: mdl-29680833

Assuntos

Asma/induzido quimicamente; Regulação para Baixo/efeitos dos fármacos; Interleucina-13/genética; Janus Quinases/genética; Lipopolissacarídeos/farmacologia; Ovalbumina; Fator de Transcrição STAT6/genética; Administração Intranasal; Animais; Asma/imunologia; Asma/metabolismo; Linhagem Celular; Modelos Animais de Doenças; Humanos; Interleucina-13/metabolismo; Janus Quinases/metabolismo; Lipopolissacarídeos/imunologia; Pulmão/metabolismo; Pulmão/patologia; Camundongos; Camundongos Endogâmicos BALB C; Mucina-5AC/genética; Mucina-5AC/metabolismo; Muco/metabolismo; Substâncias Protetoras/farmacologia; Fator de Transcrição STAT6/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Asthma; IL-13; JAK-STAT6; Lps; Mucus hypersecretion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Regulação para Baixo / Ovalbumina / Lipopolissacarídeos / Interleucina-13 / Fator de Transcrição STAT6 / Janus Quinases Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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