HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians.
Hum Immunol
; 79(7): 527-529, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29684411
ABSTRACT
We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on a Next Generation Sequencing platform. Data were analyzed using Arlequin and Pypop software. No significant deviations from Hardy-Weinberg Equilibrium were noted at any of the loci studied. We discuss the representability for the Norwegian population and argue that the presented HLA data could serve as a Norwegian reference panel.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-A
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Antígenos HLA-B
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Antígenos HLA-C
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Sistema de Registros
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Cadeias beta de HLA-DP
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Cadeias beta de HLA-DQ
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Cadeias HLA-DRB1
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article