Proteomic Analysis of Exosomes and Its Application in HIV-1 Infection.
Proteomics Clin Appl
; 12(5): e1700142, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-29687643
ABSTRACT
Exosomes are 30-100 nm extracellular vesicles secreted from late endosomes by various types of cells. Numerous studies have suggested that exosomes play significant roles in human immunodeficiency virus 1 (HIV-1) biogenesis. Proteomics coupled with exosome fractionation has been successfully used to identify various exosomal proteins and helped to uncover the interactions between exosomes and HIV-1. To inform the current progress in the intersection of exosome, proteomics, and HIV-1, this review is focused on i) analyzing different exosome isolation, purification methods, and their implications in HIV-1 studies; ii) evaluating the roles of various proteomic techniques in defining exosomal contents; iii) discussing the research and clinical applications of proteomics and exosome in HIV-1 biology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
HIV-1
/
Proteômica
/
Exossomos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article