Association of a cholesteryl ester transfer protein variant (rs1800777) with fat mass, HDL cholesterol levels, and metabolic syndrome.
Endocrinol Diabetes Nutr (Engl Ed)
; 65(7): 387-393, 2018.
Article
em En, Es
| MEDLINE
| ID: mdl-29705571
ABSTRACT
BACKGROUND:
There is little evidence of the association between CETP SNPs and obesity and/or related metabolic parameters.OBJECTIVE:
To analyze the association of the polymorphism rs1800777 of the CETP gene with anthropometric parameters, lipid profile, metabolic syndrome and its components, and adipokine levels in obese subjects without type 2 diabetes mellitus or hypertension.DESIGN:
A population of 1005 obese subjects was analyzed. Electrical bioimpedance was performed, and blood pressure, presence of metabolic syndrome, dietary intake, physical activity, and biochemical tests were recorded.RESULTS:
Nine hundred and sixty eight patients (96.3%) had the GG genotype, 37 patients the GA genotype (3.7%) (no AA genotype was detected). Fat mass (delta 4.4±1.1kg; p=0.04), waist circumference (delta 5.6±2.1cm; p=0.02), and waist to hip ratio (delta 0.04±0.01cm; p=0.01) were higher in A allele carriers than in non-A allele carriers. HDL cholesterol levels were lower in A allele carriers than in non-A allele carriers (delta 4.2±1.0mg/dL; p=0.04). In the logistic regression analysis, the GA genotype was associated to an increased risk of central obesity (OR 7.55, 95% CI 1.10-55.70, p=0.02) and low HDL cholesterol levels (OR 2.46, 95% CI 1.23-4.91, p=0.014).CONCLUSION:
The CETP variant at position +82 is associated to lower HDL cholesterol levels, increased fat mass, and central obesity in obese subjects. These results may suggest a potential role of this variant gene in pathophysiology of adipose tissue.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
/
Síndrome Metabólica
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Proteínas de Transferência de Ésteres de Colesterol
/
HDL-Colesterol
Idioma:
En
/
Es
Ano de publicação:
2018
Tipo de documento:
Article