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Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Ho, Hoangdung; Miu, Anh; Alexander, Mary Kate; Garcia, Natalie K; Oh, Angela; Zilberleyb, Inna; Reichelt, Mike; Austin, Cary D; Tam, Christine; Shriver, Stephanie; Hu, Huiyong; Labadie, Sharada S; Liang, Jun; Wang, Lan; Wang, Jian; Lu, Yan; Purkey, Hans E; Quinn, John; Franke, Yvonne; Clark, Kevin; Beresini, Maureen H; Tan, Man-Wah; Sellers, Benjamin D; Maurer, Till; Koehler, Michael F T; Wecksler, Aaron T; Kiefer, James R; Verma, Vishal; Xu, Yiming; Nishiyama, Mireille; Payandeh, Jian; Koth, Christopher M.
Afiliação
  • Ho H; Structural Biology, Genentech Inc., San Francisco, CA, USA.
  • Miu A; Biochemical and Cellular Pharmacology, Genentech Inc., San Francisco, CA, USA.
  • Alexander MK; Infectious Diseases, Genentech Inc., San Francisco, CA, USA.
  • Garcia NK; Protein Analytical Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Oh A; Structural Biology, Genentech Inc., San Francisco, CA, USA.
  • Zilberleyb I; Biomolecular Resources, Genentech Inc., San Francisco, CA, USA.
  • Reichelt M; Pathology, Genentech Inc., San Francisco, CA, USA.
  • Austin CD; Pathology, Genentech Inc., San Francisco, CA, USA.
  • Tam C; Biomolecular Resources, Genentech Inc., San Francisco, CA, USA.
  • Shriver S; Biomolecular Resources, Genentech Inc., San Francisco, CA, USA.
  • Hu H; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Labadie SS; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Liang J; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Wang L; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Wang J; WuXi Apptec. Co. Ltd., Shanghai, China.
  • Lu Y; WuXi Apptec. Co. Ltd., Shanghai, China.
  • Purkey HE; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Quinn J; Biochemical and Cellular Pharmacology, Genentech Inc., San Francisco, CA, USA.
  • Franke Y; Biomolecular Resources, Genentech Inc., San Francisco, CA, USA.
  • Clark K; Biochemical and Cellular Pharmacology, Genentech Inc., San Francisco, CA, USA.
  • Beresini MH; Biochemical and Cellular Pharmacology, Genentech Inc., San Francisco, CA, USA.
  • Tan MW; Infectious Diseases, Genentech Inc., San Francisco, CA, USA.
  • Sellers BD; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Maurer T; Structural Biology, Genentech Inc., San Francisco, CA, USA.
  • Koehler MFT; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Wecksler AT; Protein Analytical Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Kiefer JR; Structural Biology, Genentech Inc., San Francisco, CA, USA.
  • Verma V; Discovery Chemistry, Genentech Inc., San Francisco, CA, USA.
  • Xu Y; Biochemical and Cellular Pharmacology, Genentech Inc., San Francisco, CA, USA.
  • Nishiyama M; Infectious Diseases, Genentech Inc., San Francisco, CA, USA.
  • Payandeh J; Structural Biology, Genentech Inc., San Francisco, CA, USA. payandeh.jian@gene.com.
  • Koth CM; Infectious Diseases, Genentech Inc., San Francisco, CA, USA. payandeh.jian@gene.com.
Nature ; 557(7704): 196-201, 2018 05.
Article em En | MEDLINE | ID: mdl-29720648
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Proteínas de Bactérias / Transportadores de Cassetes de Ligação de ATP / Antibacterianos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Proteínas de Bactérias / Transportadores de Cassetes de Ligação de ATP / Antibacterianos Idioma: En Ano de publicação: 2018 Tipo de documento: Article