Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.

Li, Ningning; Zhang, Ying; Sidlauskas, Kastytis; Ellis, Matthew; Evans, Ian; Frankel, Paul; Lau, Joanne; El-Hassan, Tedani; Guglielmi, Loredana; Broni, Jessica; Richard-Loendt, Angela; Brandner, Sebastian

Li, Ningning; Zhang, Ying; Sidlauskas, Kastytis; Ellis, Matthew; Evans, Ian; Frankel, Paul; Lau, Joanne; El-Hassan, Tedani; Guglielmi, Loredana; Broni, Jessica; Richard-Loendt, Angela; Brandner, Sebastian.

Afiliação

Li N; Department of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK. linn29@mail.sysu.edu.cn.
Zhang Y; The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China. linn29@mail.sysu.edu.cn.
Sidlauskas K; Department of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Ellis M; Department of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Evans I; Department of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Frankel P; Division of Medicine, University College London, University Street, London, WC1E 6JF, UK.
Lau J; Division of Medicine, University College London, University Street, London, WC1E 6JF, UK.
El-Hassan T; Department of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Guglielmi L; Division of Neuropathology, the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust Queen Square, London, WC1N 3BG, UK.
Broni J; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
Richard-Loendt A; Department of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Brandner S; UCL IQPath laboratory, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

Oncogene ; 37(31): 4313-4333, 2018 08.

Article em En | MEDLINE | ID: mdl-29720725

Assuntos

Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patologia; Glioma/genética; Glioma/patologia; MicroRNAs/genética; Receptores Acoplados a Proteínas G/genética; Células-Tronco/patologia; Animais; Apoptose/genética; Astrocitoma/genética; Astrocitoma/patologia; Biomarcadores Tumorais/genética; Diferenciação Celular/genética; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Regulação para Baixo/genética; Glioblastoma/genética; Glioblastoma/patologia; Humanos; Camundongos; Oligodendroglioma/genética; Oligodendroglioma/patologia; Fatores de Transcrição/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Neoplasias Encefálicas / MicroRNAs / Receptores Acoplados a Proteínas G / Glioma Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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