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Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.
Zuo, Haoxiao; Han, Bing; Poppinga, Wilfred J; Ringnalda, Lennard; Kistemaker, Loes E M; Halayko, Andrew J; Gosens, Reinoud; Nikolaev, Viacheslav O; Schmidt, Martina.
Afiliação
  • Zuo H; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
  • Han B; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, GRIAC, Groningen, The Netherlands.
  • Poppinga WJ; Institute of Experimental Cardiovascular Research, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Ringnalda L; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
  • Kistemaker LEM; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, GRIAC, Groningen, The Netherlands.
  • Halayko AJ; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
  • Gosens R; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, GRIAC, Groningen, The Netherlands.
  • Nikolaev VO; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
  • Schmidt M; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
Br J Pharmacol ; 175(14): 2988-3006, 2018 07.
Article em En | MEDLINE | ID: mdl-29722436
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fumaça / AMP Cíclico / Nucleotídeo Cíclico Fosfodiesterase do Tipo 3 / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Produtos do Tabaco Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fumaça / AMP Cíclico / Nucleotídeo Cíclico Fosfodiesterase do Tipo 3 / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Produtos do Tabaco Idioma: En Ano de publicação: 2018 Tipo de documento: Article