Your browser doesn't support javascript.
loading
Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation.
Frank, Steven J; Blanchard, Pierre; Lee, J Jack; Sturgis, Erich M; Kies, Merrill S; Machtay, Mitchell; Vikram, Bhadrasain; Garden, Adam S; Rosenthal, David I; Gunn, G Brandon; Fuller, C David; Hutcheson, Katherine; Lai, Stephen; Busse, Paul M; Lee, Nancy Y; Lin, Alexander; Foote, Robert L.
Afiliação
  • Frank SJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: sjfrank@mdanderson.org.
  • Blanchard P; Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France.
  • Lee JJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Sturgis EM; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Kies MS; Department of Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Machtay M; Department of Radiation Oncology, UH Cleveland Medical Center, Cleveland, OH.
  • Vikram B; Clinical Radiation Oncology Branch, National Cancer Institute, Bethesda, MD.
  • Garden AS; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Rosenthal DI; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Gunn GB; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Fuller CD; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Hutcheson K; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Lai S; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Busse PM; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA.
  • Lee NY; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Lin A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.
  • Foote RL; Department of Radiation Oncology, The Mayo Clinic, Rochester, MN.
Semin Radiat Oncol ; 28(2): 108-113, 2018 04.
Article em En | MEDLINE | ID: mdl-29735186
Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors. After significant input from numerous stakeholders, the phase III portion of the randomized trial was redesigned as a noninferiority trial with progression-free survival as the primary endpoint. The process by which that redesign took place is described here.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Neoplasias Orofaríngeas / Ensaios Clínicos Controlados Aleatórios como Assunto / Fótons / Radioterapia de Intensidade Modulada / Terapia com Prótons Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Neoplasias Orofaríngeas / Ensaios Clínicos Controlados Aleatórios como Assunto / Fótons / Radioterapia de Intensidade Modulada / Terapia com Prótons Idioma: En Ano de publicação: 2018 Tipo de documento: Article