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Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators.
Gerlach, Kai; Hobson, Scott; Eickmeier, Christian; Groß, Ulrike; Braun, Clemens; Sieger, Peter; Garneau, Michel; Hoerer, Stefan; Heine, Niklas.
Afiliação
  • Gerlach K; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany. Electronic address: kai.gerlach@boehringer-ingelheim.com.
  • Hobson S; Central Nervous System Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
  • Eickmeier C; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany. Electronic address: christian.eickmeier@boehringer-ingelheim.com.
  • Groß U; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
  • Braun C; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
  • Sieger P; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
  • Garneau M; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
  • Hoerer S; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
  • Heine N; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach an der Riss, Germany.
Bioorg Med Chem ; 26(12): 3227-3241, 2018 07 23.
Article em En | MEDLINE | ID: mdl-29735425
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Secretases da Proteína Precursora do Amiloide / Imidazóis Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Secretases da Proteína Precursora do Amiloide / Imidazóis Idioma: En Ano de publicação: 2018 Tipo de documento: Article