Affinity capillary electrophoresis for identification of active drug candidates in myotonic dystrophy type 1.

Neaga, Ioan O; Hambye, Stephanie; Bodoki, Ede; Palmieri, Claudio; Ansseau, Eugénie; Belayew, Alexandra; Oprean, Radu; Blankert, Bertrand

Neaga, Ioan O; Hambye, Stephanie; Bodoki, Ede; Palmieri, Claudio; Ansseau, Eugénie; Belayew, Alexandra; Oprean, Radu; Blankert, Bertrand.

Afiliação

Neaga IO; Laboratory of Pharmaceutical Analysis, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Place du Parc 20, 7000, Mons, Belgium.
Hambye S; Analytical Chemistry Department, "Iuliu HaÈieganu" University of Medicine and Pharmacy, 4, Louis Pasteur St, 400349, Cluj-Napoca, Romania.
Bodoki E; Laboratory of Pharmaceutical Analysis, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Place du Parc 20, 7000, Mons, Belgium.
Palmieri C; Analytical Chemistry Department, "Iuliu HaÈieganu" University of Medicine and Pharmacy, 4, Louis Pasteur St, 400349, Cluj-Napoca, Romania.
Ansseau E; Laboratory of Pharmaceutical Analysis, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Place du Parc 20, 7000, Mons, Belgium.
Belayew A; Laboratory of Molecular Biology, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Place du Parc 20, 7000, Mons, Belgium.
Oprean R; Laboratory of Molecular Biology, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Place du Parc 20, 7000, Mons, Belgium.
Blankert B; Analytical Chemistry Department, "Iuliu HaÈieganu" University of Medicine and Pharmacy, 4, Louis Pasteur St, 400349, Cluj-Napoca, Romania.

Anal Bioanal Chem ; 410(18): 4495-4507, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29736701

Assuntos

Avaliação Pré-Clínica de Medicamentos/métodos; Eletroforese Capilar/métodos; Distrofia Miotônica/tratamento farmacológico; Benzamidinas/química; Benzamidinas/farmacologia; Avaliação Pré-Clínica de Medicamentos/economia; Eletroforese Capilar/economia; Células HeLa; Humanos; Ligantes; Pentamidina/química; Pentamidina/farmacologia; Motivos de Ligação ao RNA/efeitos dos fármacos; Bibliotecas de Moléculas Pequenas/química; Bibliotecas de Moléculas Pequenas/farmacologia

Palavras-chave

Affinity capillary electrophoresis; Fluorescence in situ hybridization; Ligand screening; Myotonic dystrophy type 1; Pentamidine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eletroforese Capilar / Avaliação Pré-Clínica de Medicamentos / Distrofia Miotônica Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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